A 77636 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A-77636 盐酸盐是一种有效的、口服活性的、选择性的、长效的多巴胺 D1 受体激动剂 (pKi=7.40；Ki=39.8 nM)。

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM). A-77636 hydrochloride shows antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor.(In Vivo):A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake in male hooded rat, due principally to a reduction in meal size and duration.

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Animal Model:Male hooded ratDosage:0.1, 0.3 and 1.0 mg/kg Administration:S.c.Result:Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.

A77636 hydrochloride

GPCR/G Protein

Dopamine Receptor

Free radical scavengers|Platelet aggregation

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145307-34-2

365.89

C20H28ClNO3

>98% (HPLC)

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C(N)[C@@H]1O[C@H]([C@@]23CC4CC(C2)CC(C3)C4)CC=5C1=CC=C(O)C5O.Cl

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(-20℃)

With Ice Pack

≥ 2 years